As expected, CBD has been reported to interact with antiepileptic drugs, antidepressants, opioid painkillers and THC, but surprisingly, it interacts with several other common medications, for example, since the consumption of CBD can interfere with the function of CYP enzymes, mixing CBD and PPIs could cause an increase in the side effects of PPIs. Taking CBD with certain antimicrobials can cause increased levels of CBD in the blood, which can lead to negative side effects of CBD. Certain antiepileptic drugs, such as carbamazepine, oxcarbazepine, phenobarbital and phenytoin, can affect CBD metabolism and cause a decrease in CBD levels. The side effects of CBD and antidepressants can also overlap, as CBD and antidepressants are associated with side effects on the central nervous system (CNS), such as sleepiness and sleep disturbances.
More than half said they wanted their doctor to provide them with more information about CBD, but 58 percent of people who informed their doctors about their consumption of CBD didn't get the safety, efficacy and dosage information they were looking for. Bemben, PharmD, BCPS, a specialist in drug interactions who tries to educate other pharmacists about possible interactions between drugs and CBD, as well as Rachna Patel, DO, a doctor who consults about medical marijuana and CBD and sells her own line of CBD products. It's important to take the CBD product to the doctor and pharmacist so that they can check the amount of CBD and other ingredients it contains, says Dr. While CBD may be useful for some patients, more research is needed to evaluate the safety and effectiveness of CBD.
A common concern among people with chronic diseases who consume CBD is whether CBD can interfere with prescription medications that can be taken for arthritis or other conditions. As the potential uses of CBD continue to expand, more people are becoming interested in over-the-counter CBD products.
