CBD has the potential to interact with many other products, including over-the-counter drugs, herbal products, and prescription drugs. Some medications should never be taken together with CBD; it may be necessary to modify or reduce the use of other medications to prevent serious problems. One aspect of CBD makes it particularly susceptible to drug interactions. CBD is not only processed by CYP enzymes, but it can also act as a CYP enzyme inhibitor.
Specifically, CBD can block enzymes that process other medications, such as certain seizure medications, antidepressants, and pain relievers. Simply put, taking CBD can cause increased blood levels and the side effects of other medications. I would consider topical cannabis preparations, such as creams or lotions, to be safe for your 86-year-old mother. The information you have found that cannabis does not enter the general circulation when applied to the skin is correct.
I anticipate that there will be no interaction with your medications when they are used in this way. Patients have reported the subjective benefits of topical cannabis preparations, and as long as the skin is intact, I would try them without worrying about unwanted effects. The side effects of CBD and antidepressants can also overlap, as CBD and antidepressants are associated with side effects in the central nervous system (CNS), such as sleepiness and sleep disturbances. While taking large amounts of CBD with warfarin or other anticoagulants may cause a harmful interaction, the risk is less worrying because the enzyme that metabolizes CBD (CYP2C1) is different.
Drug interactions with CBD are more common in patients with seizures, especially those who use high doses of CBD. As the potential uses of CBD continue to expand, more people are becoming interested in over-the-counter CBD products. Because the consumption of CBD can interfere with the function of CYP enzymes, mixing CBD and PPIs could lead to an increase in the side effects of PPIs. However, more research is needed to determine the severity of CBD interactions between different medications and to develop recommendations for taking them together with CBD.
While CBD may be useful for some patients, more research is needed to assess the safety and effectiveness of CBD. Bemben, PharmD, BCPS, a drug interaction specialist who tries to educate other pharmacists about possible interactions between drugs and CBD, as well as Rachna Patel, DO, a doctor who consults on medical marijuana and CBD and sells her own line of CBD products. If you have glaucoma and start using CBD products, I recommend that you have your eye pressure checked to determine if CBD is causing high blood pressure. More than half said they wanted their doctor to provide them with more information about CBD, but 58 percent of people who informed their doctors about their consumption of CBD didn't get the safety, efficacy and dosage information they were looking for.
Although no cases of interactions between CBD and these drugs have been described in the scientific literature, people who use these drugs and high doses of CBD should monitor for bruising and bleeding easily. Taking CBD with certain antimicrobials can cause increased levels of CBD in the blood, which can lead to negative side effects of CBD. “It's important to take the CBD product to the doctor and pharmacist so that they can check the amount of CBD and other ingredients it contains,” says Dr. A common concern among people with chronic diseases who consume CBD is whether CBD can interfere with prescription medications that can be taken for arthritis or other conditions.
Certain antiepileptic drugs, such as carbamazepine, oxcarbazepine, phenobarbital and phenytoin, can affect CBD metabolism and cause a decrease in CBD levels...
